Open AccessVisual spatial learning outcomes for clinical trials in neurofibromatosis type 1
Author(s) -
Ullrich Nicole J.,
Payne Jonathan M.,
Walsh Karin S.,
Cutter Gary,
Packer Roger,
North Kathryn,
ReyCasserly Celiane
Publication year - 2020
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.50976
Subject(s) - medicine , cognition , task (project management) , spatial learning , lovastatin , neurofibromatosis , clinical trial , pathology , psychiatry , management , cholesterol , economics
Cognitive problems are common in children with neurofibromatosis type 1, representing a significant source of lifelong morbidity. Assessment of cognitive function has been challenging in the setting of clinical trials. Spatial learning deficits may be an important target for cognitive interventions. We leveraged a large, international cognitive study in affected children with NF1 treated with lovastatin to assess spatial learning using the “Arena Maze”, a portable, computerized task that allows for retesting in the same environment. As with the parent study, spatial learning assessed with this task did not improve with lovastatin treatment.