Open AccessClinical outcome measures following plasma exchange for MG exacerbation
Author(s) -
Raja Shruti M.,
Howard James F.,
Juel Vern C.,
Massey Janice M.,
Chopra Manisha,
Guptill Jeffrey T.
Publication year - 2019
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.50901
Subject(s) - medicine , exacerbation , therapeutic plasma exchange , outcome (game theory) , intensive care medicine , mathematical economics , mathematics
Our objective is to report longitudinal results of the MG‐ADL, MG‐Composite, MG‐MMT, and MG‐QoL15 in an open‐label trial of therapeutic plasma exchange in myasthenia gravis. Ten MG patients experiencing exacerbation had assessments prior to, immediately following, and at selected time points post‐TPE. Changes from baseline to 2 weeks post‐TPE were: MG‐ADL median −5.0, P < 0.0033, MG‐QoL15 median −13.0, P < 0.001, MG‐MMT median −10.0, P < 0.0001, and MG‐Composite median −10.0, P < 0.005. TPE produced a rapid, clinically significant change in all instruments, indicating these outcome measures are robust endpoints for clinical trials of rapidly efficacious MG therapies.