Open AccessResponsive neurostimulation targeting anterior thalamic nucleus in generalized epilepsy
Author(s) -
Herlopian Aline,
Cash Sydney S.,
Eskandar Emad M.,
Jennings Tara,
Cole Andrew J.
Publication year - 2019
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.50858
Subject(s) - neurostimulation , medicine , epilepsy , ictal , intractable epilepsy , neuroscience , deep brain stimulation , generalized epilepsy , thalamus , stimulation , anesthesia , pathology , psychiatry , psychology , radiology , disease , parkinson's disease
Responsive neurostimulation (RNS) has emerged as an adjunctive treatment modality for patients with intractable focal epilepsy who are not surgical candidates or have more than one ictal onset focus. We report a 34‐year‐old patient with intractable, childhood‐onset, genetic generalized epilepsy (GGE) with tonic, atonic, myoclonic and absence seizures treated with RNS. Strip electrodes over the right posterior frontal cortex and depth electrodes placed in the right anterior nucleus were used for event detection and responsive stimulation. Two‐year follow‐up revealed 90–95% clinical seizure reduction. This case suggests that refractory GGE may be effectively treated with RNS targeting thalamocortical networks.