Open AccessEarly ictal recruitment of midline thalamus in mesial temporal lobe epilepsy
Author(s) -
Romeo Andrew,
Issa Roach Alexandra T.,
Toth Emilia,
Chaitanya Ganne,
Ilyas Adeel,
Riley Kristen O.,
Pati Sandipan
Publication year - 2019
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.50835
Subject(s) - thalamus , ictal , mesial temporal lobe epilepsy , hippocampus , medicine , neuroscience , epilepsy , temporal lobe , stereoelectroencephalography , electroencephalography , psychology
The causal role of midline thalamus in the initiation and early organization of mesial temporal lobe seizures is studied. Three patients undergoing stereoelectroencephalography were enrolled for the placement of an additional depth electrode targeting the midline thalamus. The midline thalamus was recruited in all three patients at varying points of seizure initiation (0–13 sec) and propagation (9–60 sec). Stimulation of either thalamus or hippocampus induced similar habitual seizures. Seizure‐induced in the hippocampus rapidly recruited the thalamus. Evoked potentials demonstrated stronger connectivity from the hippocampus to the thalamus than in the opposite direction. The midline thalamus can be within the seizure initiation and symptomatogenic circuits.