Open AccessBiomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients
Author(s) -
Antelmi Elena,
Pizza Fabio,
Donadio Vincenzo,
Filardi Marco,
Sosero Yuri L.,
Incensi Alex,
Vandi Stefano,
Moresco Monica,
Ferri Raffaele,
Marelli Sara,
FeriniStrambi Luigi,
Liguori Rocco,
Plazzi Giuseppe
Publication year - 2019
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.50833
Subject(s) - narcolepsy , medicine , polysomnography , pathological , rem sleep behavior disorder , synucleinopathies , pathophysiology , rapid eye movement sleep , modafinil , biopsy , sleep (system call) , pathology , eye movement , alpha synuclein , psychiatry , parkinson's disease , ophthalmology , disease , apnea , computer science , operating system
To search for discriminating biomarkers, 30 patients with idiopathic rapid‐eye‐movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated α ‐synuclein deposits and whole‐night video‐polysomnography. Skin biopsy was positive for phosphorylated α ‐synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video‐polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.