Open Access1 H‐ 31 P magnetic resonance spectroscopy: effect of biotin in multiple sclerosis
Author(s) -
Guillevin Carole,
Agius Pierre,
Naudin Mathieu,
Herpe Guillaume,
Ragot Stéphanie,
Maubeuge Nicolas,
Philippe Neau Jean,
Guillevin Rémy
Publication year - 2019
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.50825
Subject(s) - medicine , multiple sclerosis , biotin , bioenergetics , magnetic resonance imaging , nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , biochemistry , immunology , radiology , chemistry , mitochondrion , physics
Biotin is thought to improve functional impairment in progressive multiple sclerosis (MS) by upregulating bioenergetic metabolism. We enrolled 19 patients suffering from progressive MS (5 primary and 14 secondary Progressive‐MS). Using cerebral multinuclear magnetic resonance spectroscopy (MMRS) and clinical evaluation before and after 6 months of biotin cure, we showed significant modifications of: PME/PDE, ATP, and lactate resonances; an improvement of EDSS Neuroscore. Our results are consistent with metabolic pathways concerned with biotin action and could suggest the usefulness of MMRS for monitoring.