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This study used  11 C‐PBR28 positron emission tomography (PET) imaging to determine whether levels of 18‐kDa translocator protein (TSPO), an inflammation‐specific biomarker, are increased in frontotemporal lobar degeneration (FTLD) patients.  11 C‐PBR28,  18 F‐FDG, and  11 C‐PIB brain PET scans, as well as magnetic resonance imaging (MRI), were conducted in four FTLD patients and 22 healthy controls.  11 C‐PBR28 scans revealed that all FTLD patients showed increased TSPO binding versus controls. Significantly greater increases in TSPO were observed in the frontal, lateral temporal, parietal, and occipital cortices, topographically consistent with individual clinical phenotypes and with brain MRI and  18 F‐FDG PET. Amyloid burden was not increased.

Neuroinflammation in frontotemporal lobar degeneration revealed by 11 C‐PBR28 PET