Open AccessCD 4 + T cells from multiple sclerosis patients respond to a commensal‐derived antigen
Author(s) -
Burgess Joseph N.,
Pant Anudeep B.,
Kasper Lloyd H.,
Colpitts Brass Sara
Publication year - 2017
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.465
Subject(s) - multiple sclerosis , bacteroides fragilis , immune system , antigen , immunology , medicine , population , in vitro , effector , disease , microbiology and biotechnology , antigen presenting cell , t cell , biology , pathology , genetics , environmental health , antibiotics
Multiple sclerosis, an immune‐mediated disease of the central nervous system, is characterized by the impaired function of regulatory cells that fail to suppress self‐reactive effector cells. We have previously found that polysaccharide A, a capsular antigen derived from the human gut commensal Bacteroides fragilis , can induce a population of regulatory T cells. Herein, we demonstrate that naïve T cells isolated from patients with multiple sclerosis have the capacity to acquire regulatory characteristics when stimulated in vitro with polysaccharide A. This study demonstrates the amplification of a regulatory T cell response by a gut‐derived commensal antigen in those with multiple sclerosis.