Open AccessHuman neural stem cell transplantation into the corpus callosum of Alzheimer's mice
Author(s) -
McGinley Lisa M.,
Kashlan Osama N.,
Chen Kevin S.,
Bruno Elizabeth S.,
Hayes John M.,
Backus Carey,
Feldman Seth,
Kashlan Bader N.,
Johe Karl,
Feldman Eva L.
Publication year - 2017
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.443
Subject(s) - corpus callosum , medicine , transplantation , neural stem cell , stem cell , neuroscience , immunosuppression , hippocampus , stem cell therapy , alzheimer's disease , disease , pathology , biology , immunology , genetics
The hippocampus has been the target of stem cell transplantations in preclinical studies focused on Alzheimer's disease, with results showing improvements in histological and behavioral outcomes. The corpus callosum is another structure that is affected early in Alzheimer's disease. Therefore, we hypothesize that this structure is a novel target for human neural stem cell transplantation in transgenic Alzheimer's disease mouse models. This study demonstrates the feasibility of targeting the corpus callosum and identifies an effective immunosuppression regimen for transplanted neural stem cell survival. These results support further preclinical development of the corpus callosum as a therapeutic target in Alzheimer's disease.