Open AccessImpact of tau and amyloid burden on glucose metabolism in Alzheimer's disease
Author(s) -
Bischof Gérard N.,
Jessen Frank,
Fliessbach Klaus,
Dronse Julian,
Hammes Jochen,
Neumaier Bernd,
Onur Oezguer,
Fink Gereon R.,
Kukolja Juraj,
Drzezga Alexander,
Eimeren Thilo
Publication year - 2016
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.339
Subject(s) - neurodegeneration , alzheimer's disease , medicine , carbohydrate metabolism , disease , amyloid (mycology) , temporal lobe , metabolism , alzheimer's disease neuroimaging initiative , positron emission tomography , neuroscience , pathology , endocrinology , biology , nuclear medicine , psychiatry , epilepsy
Abstract In a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [ 18 F] AV ‐1451) and beta‐amyloid burden (measured with [ 11 C]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [ 18 F] FDG ‐ PET ) in patients with Alzheimer's disease. Across brain regions, we observed an interactive effect of beta‐amyloid burden and tau deposition on glucose metabolism which was most pronounced in the parietal lobe. Elevated beta‐amyloid burden was associated with a stronger influence of tau accumulation on glucose metabolism. Our data provide the first in vivo insights into the differential contribution of A β and tau to neurodegeneration in Alzheimer's disease.