Open AccessHypertension drives parenchymal β‐amyloid accumulation in the brain parenchyma
Author(s) -
Bueche Celine Z.,
Hawkes Cheryl,
Garz Cornelia,
Vielhaber Stefan,
Attems Johannes,
Knight Robert T.,
Reymann Klaus,
Heinze HansJochen,
Carare Roxana O.,
Schreiber Stefanie
Publication year - 2014
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.27
Subject(s) - parenchyma , medicine , stroke (engine) , pathology , disease , amyloid (mycology) , perivascular space , engineering , mechanical engineering
Abstract There is substantial controversy regarding the causative role of amyloid β (Aβ) deposition in Alzheimer's disease ( AD ). The cerebrovasculature plays an important role in the elimination of Aβ from the brain and hypertension is a well‐known risk factor for AD . In spontaneously hypertensive stroke‐prone rats ( SHRSP ), an animal model of chronic arterial hypertension, cerebral small vessel disease ( CSVD ) leads to age‐dependent parenchymal Aβ accumulation similar to that observed in AD . These data approve the neuropathological link between CSVD and AD , confirm the challenge that parenchymal Aβ deposition is a specific marker for AD and disclose the meaning of SHRSP as valid experimental model to investigate the association between hypertension, CSVD , and Aβ plaques.