Open AccessCerebrospinal fluid aquaporin‐4‐immunoglobulin G disrupts blood brain barrier
Author(s) -
Asgari Nasrin,
Berg Carsten Tue,
Mørch Marlene Thorsen,
Khorooshi Reza,
Owens Trevor
Publication year - 2015
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.221
Subject(s) - aquaporin 4 , cerebrospinal fluid , medicine , blood–brain barrier , pathology , horseradish peroxidase , antibody , parenchyma , immunoglobulin g , astrocyte , neuromyelitis optica , immunology , central nervous system , chemistry , endocrinology , biochemistry , enzyme
To clarify the significance of immunoglobulin G autoantibody specific for the astrocyte water channel aquaporin‐4 in cerebrospinal fluid, aquaporin‐4‐immunoglobulin G from a neuromyelitis optica patient was administered intrathecally to naïve mice, and the distribution and pathogenic impact was evaluated. A distinct distribution pattern of aquaporin‐4‐immunoglobulin G deposition was observed in the subarachnoid and subpial spaces where vessels penetrate the brain parenchyma, via a paravascular route with intraparenchymal perivascular deposition. Perivascular astrocyte‐destructive lesions were associated with blood‐borne horseradish peroxidase leakage indicating blood‐brain barrier breakdown. The cerebrospinal fluid aquaporin‐4‐immunoglobulin G therefore distributes widely in brain to initiate astrocytopathy and blood‐brain barrier breakdown.