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Strain‐level immunomodulatory variation of gut bacteria
Author(s) -
Hajjo Haitham,
GevaZatorsky Naama
Publication year - 2021
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.14057
Subject(s) - biology , bacteria , strain (injury) , immune system , gut flora , microbiology and biotechnology , gut bacteria , phylogenetics , host (biology) , genetics , immunology , gene , anatomy
The gut microbiota and the immune system have co‐evolved to interact and cooperate in many ways. A recent study characterizing the immunomodulatory effects of over 60 different human‐derived gut microbes across phyla showed that bacteria‐induced immunomodulations are not dictated by the bacterial phylogeny. Yet, it remains unclear whether strains from the same species induce the same immunomodulatory effects on the host. We analyzed the strain‐level data from this recent study and found that strains from the same species can induce distinct and sometimes even opposing immunophenotypes. Hence, we suggest that the immunomodulatory capabilities of gut bacteria can be strain‐specific.