Premium
An inventory of lysosomal ABC transporters
Author(s) -
Szakacs Gergely,
Abele Rupert
Publication year - 2020
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13967
Subject(s) - endosome , atp binding cassette transporter , lysosome , transporter , microbiology and biotechnology , biology , multidrug resistance associated protein 2 , intracellular , organelle , vesicular transport proteins , chemistry , biochemistry , enzyme , gene , vacuolar protein sorting
ABC transporters fulfill diverse physiological functions in different cellular localizations ranging from the plasma membrane to intracellular membranous compartments. Several ABC transporters have been spotted in the endolysosomal system, which consists of endosomes, autophagosomes, lysosomes, and lysosome‐related organelles. In this review, we present an overview of lysosomal ABC transporters including ABCA2, ABCA3, ABCA5, ABCB6, ABCB9, and ABCD4, discussing their trafficking routes, putative substrates, potential physiological functions, and associated diseases. In addition, we offer a critical evaluation of the literature linking ABC transporters to lysosomal drug sequestration, examining pitfalls associated with in vitro models of drug resistance.