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The gut microbiome participates in transgenerational inheritance of low‐temperature responses in Drosophila melanogaster
Author(s) -
Zare Aman,
Johansson AnnaMia,
Karlsson Edvin,
Delhomme Nicolas,
Stenberg Per
Publication year - 2018
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.13278
Subject(s) - drosophila melanogaster , biology , microbiome , offspring , genetics , transgenerational epigenetics , germline , inheritance (genetic algorithm) , gene , melanogaster , gut microbiome , drosophila (subgenus) , pregnancy
Environmental perturbations induce transcriptional changes, some of which may be inherited even in the absence of the initial stimulus. Previous studies have focused on transfers through the germline although microbiota is also passed on to the offspring. Thus, we inspected the involvement of the gut microbiome in transgenerational inheritance of environmental exposures in Drosophila melanogaster . We grew flies in the cold versus control temperatures and compared their transcriptional patterns in both conditions as well as in their offspring. F2 flies grew in control temperature, while we controlled their microbiota acquisition from either F1 sets. Transcriptional status of some genes was conserved transgenerationally, and a subset of these genes, mainly expressed in the gut, was transcriptionally dependent on the acquired microbiome.