English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Micro RNAs (miRNAs) serve as crucial post‐transcriptional regulators in a variety of essential cell fate decisions. However, the contribution of mRNA–miRNA mutual regulation to bistability is not fully understood. In the present study, we built a set of mathematical models of mRNA–miRNA interactions and systematically analyzed the sensitivity of the response curves under various conditions. Our findings indicate that mRNA–miRNA reciprocal regulation could manifest ultrasensitivity to subserve the generation of bistability when equipped with a positive feedback loop. We also find that the region of bistability is expanded by a stronger competing endogenous mRNA. Interestingly, bistability can be generated without a feedback loop if multiple miRNA binding sites exist on a target mRNA. Thus, we demonstrate the importance of simple mRNA–miRNA reciprocal regulation in cell fate decisions.

Reciprocal regulation between mRNA and microRNA enables a bistable switch that directs cell fate decisions