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Direct interaction of Ste11 and Mkk1/2 through Nst1 integrates high‐osmolarity glycerol and pheromone pathways to the cell wall integrity MAPK pathway
Author(s) -
Leng Gang,
Song Kiwon
Publication year - 2016
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1002/1873-3468.12039
Subject(s) - mapk/erk pathway , pheromone , microbiology and biotechnology , chemistry , signal transduction , heat stress , mitogen activated protein kinase , osmotic concentration , biology , biochemistry , genetics , zoology
Coordination and cross talks of MAPK pathways are critical for signaling efficiency, but their mechanisms are not well understood. Slt2, the MAP kinase of cell wall integrity pathway ( CWI ), is activated by heat stress even in the absence of upstream components of this pathway, suggesting a supplementary input for Slt2 activation. Here, we identify a new interaction of Ste11 and Mkk1, mediated by Nst1 that connects the high‐osmolarity glycerol and pheromone pathways directly to CWI pathway in response to heat and pheromone. We suggest that Ser 407 and Thr 411 are novel residues of Mkk1 activated by these MAPK pathways.