Open AccessRisk of Pancreatic Cancer Among Individuals With Pathogenic Variants in the ATM Gene
Author(s) -
FangChi Hsu,
Nicholas J. Roberts,
Erica J. Childs,
Nancy Porter,
Kari G. Rabe,
Ayelet Borgida,
Chinedu Ukaegbu,
Michael Goggins,
Ralph H. Hruban,
George Zogopoulos,
Sapna Syngal,
Steven Gallinger,
Gloria M. Petersen,
Alison P. Klein
Publication year - 2021
Publication title -
jama oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 8.846
H-Index - 99
eISSN - 2374-2445
pISSN - 2374-2437
DOI - 10.1001/jamaoncol.2021.3701
Subject(s) - pancreatic cancer , penetrance , medicine , cancer , germline mutation , family history , oncology , germline , proband , population , genetics , mutation , gene , biology , phenotype , environmental health
Pathogenic germline variants in the ATM gene have been associated with pancreatic cancer risk. Although genetic testing identifies these variants in approximately 1% to 3% of unselected patients with pancreatic cancer, the lifetime risk of pancreatic cancer among individuals with pathogenic ATM variants has not been well estimated.
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