Open AccessHeterogeneity of Treatment Effects in an Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale After Stroke
Author(s) -
David M. Kent,
Jeffrey L. Saver,
Scott E. Kasner,
Jason Nelson,
John D. Carroll,
Gilles Châtellier,
Geneviève Dérumeaux,
Anthony J. Furlan,
Howard C. Herrmann,
Peter Jüni,
Jong S. Kim,
Benjamin Koethe,
Pil Hyung Lee,
Bénédicte Lefebvre,
Heinrich P. Mattle,
Bernhard Meier,
Mark Reisman,
Richard W. Smalling,
Lars Soendergaard,
JaeKwan Song,
JeanLouis Mas,
David E. Thaler
Publication year - 2021
Publication title -
jama
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.688
H-Index - 680
eISSN - 1538-3598
pISSN - 0098-7484
DOI - 10.1001/jama.2021.20956
Subject(s) - medicine , patent foramen ovale , stroke (engine) , randomized controlled trial , paradoxical embolism , hazard ratio , subgroup analysis , surgery , cardiology , meta analysis , confidence interval , migraine , engineering , mechanical engineering
Patent foramen ovale (PFO)-associated strokes comprise approximately 10% of ischemic strokes in adults aged 18 to 60 years. While device closure decreases stroke recurrence risk overall, the best treatment for any individual is often unclear.
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