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Cell migration is a fundamental process for life and is highly dependent onthe dynamical and mechanical properties of the cytoskeleton. Intensive physicaland biochemical crosstalk between actin, microtubules, and intermediatefilaments ensures their coordination to facilitate and enable migration. Inthis review we discuss the different mechanical aspects that govern cellmigration and provide, for each mechanical aspect, a novel perspective byjuxtaposing two complementary approaches to the biophysical study ofcytoskeletal crosstalk: live-cell studies (often referred to as top-downstudies) and cell-free studies (often referred to as bottom-up studies). Wesummarize the main findings from both experimental approaches, and we provideour perspective on bridging the two perspectives to address the open questionsof how cytoskeletal crosstalk governs cell migration and makes cells move.

How cytoskeletal crosstalk makes cells move: bridging cell-free and cell studies