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Based on 4.5 fb$^{-1}$ of $e^{+}e^{-}$ collision data accumulated atcenter-of-mass energies between $4599.53$ MeV and $4698.82$ MeV with the BESIIIdetector, the decay $\Lambda_{c}^{+}\to nK_{S}^{0}\pi^+\pi^0$ is observed forthe first time with a significance of $9.2\sigma$. The branching fraction ismeasured to be $(0.85\pm0.13\pm0.03)\%$, where the first uncertainty isstatistical and the second systematic, which differs from the theoreticalprediction based on isospin by 4.4$\sigma$. This indicates that there may beresonant contributions or some unknown dynamics in this decay.

First observation of the decay $\Lambda^+_c\to nK^{0}_{S}\pi^+\pi^0$