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In developing countries, healthcare challenges and expensive infertilitytreatments has resulted in resurgent interest in medicinal plants. This studywas designed to determine if Curcubita pepo seed can enhance female fertility,by assessing the reproductive outcome in female wistar rats treated withn-hexane (nHE), dichloromethane (DCM) and aqueous ethanol (Aq. Eth) extracts ofCurcubita pepo seed. Total of 48 rats randomly grouped into 12 (n=4), weretreated for 21 days by oral gavage as follows: A (control) = 0.5ml 20% tween 80(vehicle); B (positive control) = 10mg/kg clomiphene citrate, C, D & E =142.86, 285.71 and 428.57 mg/kg nHE; F, G & H = 142.86, 285.71 and 428.57 mg/kgDCM ; and I, J & K =142.86, 285.71 and 428.57 mg/kg Aq.Eth extracts. Group L(positive control 2) = 10mg/kg clomiphene citrate for 8 days. Followingtreatment, the rats were paired with males for mating, designating theconfirmation day as gestational day 0 (GD 0). On GD 20, the animals werelaparatomised and reproductive outcome was determined by assessing foetalweight, foetal crown-rump length, litter size, number of implantation andresorption sites. Results showed all extracts had no significant (p >0.05)effect on the reproductive outcome indices. Clomiphene citrate significantlydecreased reproductive outcome indices. In conclusion, Cucurbita pepo seed didnot enhance the reproductive outcome of treated female rats at the doses andduration used in this study. This finding may serve as a springboard for futurestudies exploring the effect of C.pepo at different doses or durations.

Reproductive outcome in female wistar rats treated with nhexane, dichloromethane and aqueous ethanol extracts of Cucurbita pepo seed