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Objective: About 12,000 people are diagnosed with lung cancer (LC) each yearin Argentina, and the diagnosis has a significant personal and family. Theobjective of this study was to characterize the Health-Related Quality of Life(HRQoL) and the economic impact in patients with LC and in their households.Methods: Observational cross-sectional study, through validated structuredquestionnaires to patients with a diagnosis of Non-Small Cell Lung Cancer(NSCLC) in two referral public health care centers in Argentina. Questionnariesused: Health-Related Quality of life (EuroQol EQ-5D-3L questionnaire);financial toxicity (COST questionnaire); productivity loss (WPAI-GH, WorkProductivity and Activity Impairment Questionnaire: General Health), andout-of-pocket expenses. Results: We included 101 consecutive patients (mean age67.5 years; 55.4% men; 57.4% with advanced disease -stage III/IV-). The meanEQ-VAS was 68.8 (SD:18.3), with 82.2% describing fair or poor health. The mostaffected dimensions were anxiety/depression, pain, and activities of dailyliving. Patients reported an average 59% decrease in their ability to performregular daily activities as measured by WPAI-GH. 54.5% reported a reduction inincome due to the disease, and 19.8% lost their jobs. The annual economicproductivity loss was estimated at USD 2,465 per person. 70.3%) of patientsreported financial toxicity. The average out-of-pocket expenditure was USD100.38 per person per month, which represented 18.5% of household income.Catastrophic expenditures were present in 37.1% of households. When performingsubgroup analysis by disease severity, all outcomes were worse in thesubpopulation with advanced disease. Conclusions Patients with NSCLC treated inpublic hospitals in Argentina have significant health-related quality of lifeand economic impact, worsening in patients with advanced disease.

Health-related Quality of life, Financial Toxicity, Productivity Loss and Catastrophic Health Expenditures After Lung Cancer Diagnosis in Argentina