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Recent work has provided new insights into the temporal specialization ofIntratelencephalic (IT) and Pyramidal tract neurons (PT). However, functionaland anatomical differences of IT and PT have not been connected yet. Thisperspective article contributes by highlighting empirical studies about theconnectivity of IT and PT as well as their specialization in sensory and motorprocessing in diverse brain regions. We further review conceptual models thatwould align with the connectivity motif. We conclude that further research isneeded to understand the role of the unidirectional connectivity from IT to PTin temporal processing and suggest concrete experiments.

Two types of pyramidal cells and their role in temporal processing