English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The epidemiological behavior of Plasmodium vivax malaria occurs acrossspatial scales including within-host, population, and metapopulation levels. Onthe within-host scale, P. vivax sporozoites inoculated in a host may formlatent hypnozoites, the activation of which drives secondary infections andaccounts for a large proportion of P. vivax illness; on the metapopulationlevel, the coupled human-vector dynamics characteristic of the population levelare further complicated by the migration of human populations across patcheswith different malaria forces of (re-)infection. To explore the interplay ofall three scales in a single two-patch model of Plasmodium vivax dynamics, weconstruct and study a system of eight integro-differential equations withperiodic forcing (arising from the single-frequency sinusoidal movement of ahuman sub-population). Under the numerically-informed ansatz that the limitingsolutions to the system are closely bounded by sinusoidal ones for certainregions of parameter space, we derive a single nonlinear equation from whichall approximate limiting solutions may be drawn, and devise necessary andsufficient conditions for the equation to have only a disease-free solution.Our results illustrate the impact of movement on P. vivax transmission andsuggest a need to focus vector control efforts on forest mosquito populations.The three-scale model introduced here provides a more comprehensive frameworkfor studying the clinical, behavioral, and geographical factors underlying P.vivax malaria endemicity.

A spatial multiscale mathematical model of Plasmodium vivax transmission