English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Radiotherapy using very-high-energy electron (VHEE) beams (50-300 MeV) hasattracted considerable attention due to its advantageous dose depositioncharacteristics, enabling deep penetration and the potential for ultra-highdose rate treatment. One promising approach to compactly delivering these highenergy electron beams in a cost-effective manner is laser wakefieldacceleration (LWFA), which offers ultra-strong accelerating gradients. However,the transition from this concept to a functional machine intended for tumortreatment is still being investigated. Here we present the first self-developedprototype for LWFA-based VHEE radiotherapy, exhibiting high compactness(occupying less than 5 square meters) and high operational stability (validatedover a period of one month). Subsequently, we employed this device to irradiatea tumor implanted in a mouse model. Following a dose delivery of $5.8\pm0.2$ Gywith precise tumor conformity, all irradiated mice exhibited pronounced controlof tumor growth. For comparison, this tumor-control efficacy was similar tothat achieved using commercial X-ray radiotherapy equipment operating atequivalent doses. These results demonstrate the potential of a compactlaser-driven VHEE system for preclinical studies involving small animal modelsand its promising prospects for future clinical translation in cancer therapy.

Experimental demonstration of mice tumor control with a laser-accelerated high-energy electron radiotherapy prototype