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Advances in gene sequencing have enabled in silico analyses of microbialgenomes and have led to the revision of concepts of microbial taxonomy andevolution. We explore deficiencies in existing multiple sequence globalalignment algorithms and introduce a new indexing scheme to partition thedynamic programming algorithm hypercube scoring tensor over processors based onthe dependency between partitions to be scored in parallel. The performance ofalgorithms is compared in the study of rpoB gene sequences of Mycoplasmaspecies.

High Performance Multiple Sequence Alignment Algorithms for Comparison of Microbial Genomes