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We describe the AMReX-Astrophysics framework for exploring the sensitivity ofastrophysical simulations to the details of a nuclear reaction network,including the number of nuclei, choice of reaction rates, and approximationsused. This is explored by modeling a simple detonation with the Castrosimulation code. The entire simulation methodology is open-source andGPU-enabled.

A Framework for Exploring Nuclear Physics Sensitivity in Numerical Simulations