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This article presents an investigation of isospin equilibration incross-bombarding $^{40,48}$Ca$+^{40,48}$Ca reactions at $35$ MeV/nucleon, bycomparing experimental data with filtered transport model calculations. Isospindiffusion is studied using the evolution of the isospin transport ratio withcentrality. The asymmetry parameter $\delta=(N-Z)/A$ of the quasiprojectile(QP) residue is used as isospin-sensitive observable, while a recent method forimpact parameter reconstruction is used for centrality sorting.A benchmark ofglobal observables is proposed to assess the relevance of the antisymmetrizedmolecular dynamics (AMD) model, coupled to GEMINI++, in the study ofdissipative collisions. Our results demonstrate the importance of consideringcluster formation to reproduce observables used for isospin transport andcentrality studies.Within the AMD model, we prove the applicability of theimpact parameter reconstruction method, enabling a direct comparison to theexperimental data for the investigation of isospin diffusion.For both, weevidence a tendency to isospin equilibration with an impact parameterdecreasing from $9$ to $3$ fm, while the full equilibration is not reached.Aweak sensitivity to the stiffness of the equation of state employed in themodel is also observed, with a better reproduction of the experimental trendfor the neutron-rich reactions.

Study of isospin diffusion from $^{40,48}$Ca$+^{40,48}$Ca experimental data at Fermi energies: direct comparisons with transport model calculations