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Various methods have been proposed to enhance image quality in ultrafastultrasound. Coherent compounding can improve image quality using multiplesteered diverging transmits when motion occurring between transmits iscorrected for. Harmonic imaging, a standard technique in conventional focusedechocardiography, has been adapted for ultrafast imaging, reducing clutter.Coherence-based approaches have also been shown to increase contrast inclinical settings by enhancing signals from coherent echoes and reducingclutter. Herein, we introduce a simple, unified framework that combinesmotion-correction, harmonic imaging, and angular-coherence, showing for thefirst time that their benefits can be combined in real-time. Validation wasconducted through in vitro testing on a spinning disk model and in vivo on 4volunteers. In vitro results confirmed the unified framework capability toachieve high contrast in large-motion contexts up to 17 cm/s. In vivo testinghighlighted proficiency in generating images of high quality during low andhigh tissue velocity phases of the cardiac cycle. Specifically, duringventricular filling, the unified framework increased the gCNR from 0.47 to 0.87when compared against coherent compounding.

A unified framework combining coherent compounding, harmonic imaging and  angular coherence for simultaneous high-quality B-mode and tissue Doppler in  ultrafast echocardiography