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Organic chemistry is undergoing a major paradigm shift, moving from alabor-intensive approach to a new era dominated by automation and artificialintelligence (AI). This transformative shift is being driven by technologicaladvances, the ever-increasing demand for greater research efficiency andaccuracy, and the burgeoning growth of interdisciplinary research. AI models,supported by computational power and algorithms, are drastically reshapingsynthetic planning and introducing groundbreaking ways to tackle complexmolecular synthesis. In addition, autonomous robotic systems are rapidlyaccelerating the pace of discovery by performing tedious tasks withunprecedented speed and precision. This article examines the multipleopportunities and challenges presented by this paradigm shift and explores itsfar-reaching implications. It provides valuable insights into the futuretrajectory of organic chemistry research, which is increasingly defined by thesynergistic interaction of automation and AI.

Transforming organic chemistry research paradigms: moving from manual efforts to the intersection of automation and artificial intelligence