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Infection control remains one of the most challenging tasks in wound care,due to growing antimicrobial resistance and ineffective infection diagnostictools at the point-of-care. To integrate therapeutic wound dressings with woundmonitoring capability at the point-of-care to enable informed clinicaldecision-making, we investigate the encapsulation of a halochromic dye, i.e.bromothymol blue (BTB), onto two commercial dressings, i.e. Aquacel Extra andPromogran, through a simple drop-casting method. Our concept leverages theinfection-associated rise in wound pH, on the one hand, and BTB's colour changecapability in the pH range of healing (pH: 5-6) and infected wounds (pH > 7),on the other hand. BTB-encapsulated samples show a prompt colour switch(yellow/orange --> blue) following 1-hour incubation at pH 8. The effect ofswelling ratio, chemical composition and microstructure is then explored todraw relationships between colour change capability and dressing dye retention.

Infection-responsivity of Commercial Dressings Through Halochromic Drop-casting