English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Optimal treatment rules can improve health outcomes on average by assigning atreatment associated with the most desirable outcome to each individual. Due toan unknown data generation mechanism, it is appealing to use flexible models toestimate these rules. However, such models often lead to complex anduninterpretable rules. In this article, we introduce an approach aimed atestimating optimal treatment rules that have higher accuracy, higher value, andlower loss from the same simple model family. We use a flexible model toestimate the optimal treatment rules and a simple model to derive interpretabletreatment rules. We provide an extensible definition of interpretability andpresent a method that - given a class of simple models - can be used to selecta preferred model. We conduct a simulation study to evaluate the performance ofour approach compared to treatment rules obtained by fitting the same simplemodel directly to observed data. The results show that our approach has loweraverage loss, higher average outcome, and greater power in identifyingindividuals who can benefit from the treatment. We apply our approach to derivetreatment rules of adjuvant chemotherapy in colon cancer patients using cancerregistry data. The results show that our approach has the potential to improvetreatment decisions.

Making accurate and interpretable treatment decisions for binary outcomes