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Current Total Skin Electron Therapy (TSET) Stanford technique for cutaneouslymphoma, established in the 70's, involves a unique irradiation setup, i.e.patient's position and beam arrangement, for all patients with ensuing greatvariability in dose distribution and difficult dose optimization. AGeant4-based simulation has been developed to explore the possibility ofpersonalizing the dose to each patient's anatomy. To achieve this optimizationof the treatment method, this project enrolls different aspects of the clinicaland computational techniques: starting with the knowledge of the experimentalparameters involving TSET practice, passing through an innovative approach tomodel the patient's anatomy, a precise description of the electron beam and avalidated configuration of the physics models handling the interactions of theelectrons and of secondary particles. The Geant4-based simulation models thepatient as a tessellated solid derived from the optical scan of her/his body,realistically reproduces the irradiation environment in detail and calculatesthe energy deposition corresponding to each facet of the patient's scannedsurface. The resulting three-dimensional dose distribution constitutes thebasis for the personalization of the medical treatement as appropriate to eachpatient's specific characteristics.

Total Skin Electron Therapy Stanford Technique Evolution With Monte Carlo Simulation Toward Personalized Treatments For Cutaneous Lymphoma