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Intensity Modulated Radiation Therapy is an effective cancer treatment.Models based on the Generalized Equivalent Uniform Dose (gEUD) provideradiation plans with excellent planning target volume coverage and lowradiation for organs at risk. However, manual adjustment of the parametersinvolved in gEUD is required to ensure that the plans meet patient-specificphysical restrictions. This paper proposes a radiotherapy planning methodologybased on bi-level optimization. We evaluated the proposed scheme in a realpatient and compared the resulting irradiation plans with those prepared byclinical planners in hospital devices. The results in terms of efficiency andeffectiveness are promising.

Bi-Level Optimization to Enhance Intensity Modulated Radiation Therapy Planning