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Background: Cardiovascular MRI (CMR) faces challenges due to the interferenceof bright fat signals in visualizing anatomical structures. Effective fatsuppression is crucial when using whole-heart CMR. Conventional methods oftenfall short due to rapid fat signal recovery and water-selective off-resonantpulses come with tradeoffs between scan time and RF energy deposit. Alipid-insensitive binomial off-resonant (LIBOR) RF pulse is introduced,addressing concerns about RF energy and scan time for CMR at 3T. Methods: Ashort LIBOR pulse was developed and implemented in a free-breathing respiratoryself-navigated whole-heart sequence at 3T. A BORR pulse with matched duration,as well as previously used LIBRE pulses, were implemented and optimized for fatsuppression in numerical simulations and validated in healthy subjects (n=3).Whole-heart CMR was performed in healthy subjects (n=5) with all four pulses.The SNR of ventricular blood, skeletal muscle, myocardium, and subcutaneousfat, and the coronary vessel sharpness and length were compared. Results:Experiments validated numerical findings and near homogeneous fat suppressionwas achieved with all pulses. Comparing the short pulses (1ms), LIBOR reducedthe RF power two-fold compared with LIBRE, and three-fold compared with BORR,and LIBOR significantly decreased overall fat SNR. The reduction in RF durationshortened the whole-heart acquisition from 8.5min to 7min. No significantdifferences in coronary arteries detection and sharpness were found whencomparing all four pulses. Conclusion: LIBOR enabled whole-heart CMR under 7minutes at 3T, with large volume fat signal suppression, while reducing RFpower compared with LIBRE and BORR. LIBOR is an excellent candidate to addressSAR problems encountered in CMR where fat suppression remains challenging andshort RF pulses are required.

Fat-free noncontrast whole-heart CMR with fast and power-optimized off-resonant water excitation pulses