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In neurosurgical procedures maximizing the resection of tumor tissue whileavoiding healthy tissue is of paramount importance and a difficult task due tomany factors, such as surrounding eloquent brain. Swiftly identifying tumortissue for removal could increase surgical outcomes. The TumorID is alaser-induced fluorescence spectroscopy device that utilizes endogenousfluorophores such as NADH and FAD to detect tumor regions. With the goal ofcreating an endoscopic tool for intraoperative tumor detection in mind, a studyof the TumorID was conducted to assess how the angle of incidence (AoI) affectsthe collected spectral response of the scanned tumor. For this study, flat andconvex NADH/FAD gellan gum phantoms were scanned at various AoI (a range of 36degrees) to observe the spectral behavior. Results showed that spectralsignature did not change significantly across flat and convex phantoms, and theArea under Curve (AUC) values calculated for each spectrum had a standarddeviation of 0.02 and 0.01 for flat and convex phantoms, respectively.Therefore, the study showed that AoI will affect the intensity of the spectralresponse, but the peaks representative of the endogenous fluorophores are stillobservable and similar. Future work includes conducting an AoI study with alonger working-distance lens, then incorporating said lens to design anendoscopic, intraoperative tumor detection device for minimally invasivesurgery, with first applications in endonasal endoscopic approaches forpituitary tumors.

Incident Angle Study for Designing an Endoscopic Tool for Intraoperative Brain Tumor Detection