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We present a methodological argument to refute the so-called many-worldsinterpretation (MWI) of quantum theory. Several known criticisms in theliterature have already pointed out problematic aspects of this interpretation,such as the lack of a satisfactory account of probabilities, or the hugeontological cost of MWI. Our criticism, however, does not go into the technicaldetails of any version of MWI, but is at the same time more general and moreradical. We show, in fact, that a whole class of theories--of which MWI is aprime example--fails to satisfy some basic tenets of science which we callfacts about natural science. The problem of approaches the likes of MWI isthat, in order to reproduce the observed empirical evidence about any concretequantum measurement outcome, they require as a tacit assumption that the theorydoes in fact apply to an arbitrarily large range of phenomena, and ultimatelyto all phenomena. We call this fallacy the holistic inference loop, and we showthat this is incompatible with the facts about natural science, rendering MWIuntenable and dooming it to be refuted.

On playing gods: The fallacy of the many-worlds interpretation