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Using a novel modeling approach based on the so-called environmental stresslevel (ESL), we develop a mathematical model to describe systematically thecollective influence of oxygen concentration and stiffness of the extracellularmatrix on the response of tumor cells to a combined chemotherapeutic treatment.We perform Bayesian calibrations of the resulting model using particle filters,with in vitro experimental data for different hepatocellular carcinoma celllines. The calibration results support the validity of our mathematical model.Furthermore, they shed light on individual as well as synergistic effects ofhypoxia and tissue stiffness on tumor cell dynamics under chemotherapy.

Using systemic modeling and Bayesian calibration to investigate the role of the tumor microenvironment on chemoresistance