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Online dose calculations before radiation treatment have applications in dosedelivery verification, plan adaptation, and treatment planning. We propose anovel CBCT imaging pipeline to enhance accuracy. Our approach aims to improveHU accuracy in CBCT images for more precise dose calculations. A quantitativeCBCT pipeline was implemented, combining data correction strategies and scatterrejection, achieving high CT number accuracy. We evaluated the pipeline'seffect using pelvis anatomy phantoms and found that dosimetric errors inquantitative CBCT-based dose calculations were minimal. In contrast, clinicalCBCT and high-performance ASG CBCT-based plans showed significant errors. Theproposed quantitative CBCT pipeline offers comparable dose calculation accuracyto the gold-standard planning CT, eliminating the need for density overridesand enabling precise dose delivery monitoring or online plan adaptations inradiation therapy.

A 2D antiscatter grid and scatter sampling based CBCT method for online dose calculations during CBCT guided radiation therapy of pelvis