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The homeostasis of epithelial tissue relies on a balance between theself-renewal of stem cell populations, cellular differentiation, and loss.Although this balance needs to be tightly regulated to avoid pathologies, suchas tumor growth, the regulatory mechanisms, both cell-intrinsic and collective,which ensure tissue steady-state are still poorly understood. Here, we developa computational model that incorporates basic assumptions of stem cell renewalinto distinct populations and mechanical interactions between cells. We findthat the model generates unexpected dynamic features: stem cells repel eachother in the bulk tissue and are thus found rather isolated, as in a number ofin vivo contexts. By mapping the system onto a gas of passive Brownianparticles with effective repulsive interactions, that arise from the generatedflows of differentiated cells, we show that we can quantitatively describe suchstem cell distribution in tissues. The interaction potential between a pair ofstem cells decays exponentially with a characteristic length that spans severalcell sizes, corresponding to the volume of cells generated per stem celldivision. Our findings may help understanding the dynamics of normal andcancerous epithelial tissues.

Mechanically-driven Stem Cell Separation in Tissues caused by Proliferating Daughter Cells