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The ability to spatially and temporally map nanoscale environments in situover extended timescales would be transformative for biology, biomedicine, andbioengineering. All nanometer objects, from nanoparticles down to singleproteins, scatter light. Interferometric scattering stands as a powerful tool,offering ultrasensitivity and resolution vital for visualizing nanoscaleentities. Interferometric scattering from an individual nanoparticle down to anindividual protein has been detected; however, resolving adjacent nanometerobjects with interferometric scattering has not yet been demonstrated. In thiswork, we present interferometric phase intensity nanoscopy to resolve adjacentnanometer objects with interferometric scattering. We demonstrate thatmultiphase and sensitivity of interferometric phase intensity nanoscopy revealsellipse Airy patterns correlated with nanostructural features. We show thateliminating background fluctuation by employing circular polarized illuminationin interferometric phase intensity nanoscopy is essential to separate proximalnanometer objects below the diffraction limit. We envision interferometricphase intensity nanoscopy for resolving a variety of adjacent nanometer objectsfrom nanoparticles down to proximal proteins in situ over extended time periodsfor wide range of applications in biology, biomedicine and bioengineering.

Resolving proximal nanometer objects below the diffraction limit with interferometric phase intensity nanoscopy