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$\alpha$-glucosidase and prolylendopeptidase has altered expression andactivity patterns in neurological disease, type 2diabetes respectively andseveral cancers. Here we screened a series 1-29 benzophenone semicarbazonederivatives for in vitro free radical scavenging, alpha-glucosidase andprolylendopeptidase inhibition activities. Seven derivatives were identified aspotential free radical scavengers, 14 as alpha-glucosidase, and 9 asprolylendopeptidase inhibitors. Kinetic studies on the most promisinginhibitors were performed. Compounds 23, 27, 25 and 28 were found as inhibitorof alpha-glucosidase, while compound 26 inhibited both prolylendopeptidase andalpha-glucosidase. The binding modes and binding free energy of the multitargeted inhibitor 26 were predicted by molecular docking studies. Theseresults provide insights on prolylendopeptidase and alpha-glucosidaseinhibition of compound 26 for further development as therapeutic agents forneoplastic, neurological, and endocrine disorders.

Benzophenone Semicarbazones as Potential alpha-glucosidase and Prolyl  Endopeptidase Inhibitor: In-vitro free radical scavenging, enzyme inhibition,  mechanistic, and molecular docking studies