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Objective: The study explored therapeutic targets and mechanisms of GegenQinlian Decoction for Helicobacter pylori infection and related gastric cancerusing network pharmacology, molecular docking, and Mendelian randomization.  Methods: Medicinal components of Gegen Qinlian Decoction were extracted fromTCMSP and HERB databases. Disease treatment targets were sourced from DisGeNETand PubChem. Interaction networks were constructed via the STRING database andvisualized using Cytoscape 3.9.1. Enrichment analysis of intersected targetswas performed using DAVID and Metascapes. Molecular docking employed AutodockTools 1.5.6 and PyMOL 2.5.2. Mendelian randomization was based on the ukb-b-531sample from UK Biobank.  Results: 146 active components and 248 targets from Gegen Qinlian Decoctionwere identified. 66 targets overlapped with Helicobacter pylori infectiongenes. Molecular docking highlighted interactions between primary drugcomponents like quercetin, wogonin, kaempferol, and target genes PTGS1, PTGS2,MAPK14. Mendelian randomization pinpointed genes like IGF2, PIK3CG, GJA1, andPLAU associated with Helicobacter pylori infection.  Conclusion: Gegen Qinlian Decoction's active components target Helicobacterpylori infection through diverse targets and pathways, presenting potentialresearch avenues.

Network Pharmacology, Molecular Docking, and MR Analysis: Targets and Mechanisms of Gegen Qinlian Decoction for Helicobacter pylori