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The grand challenge of protein engineering is the development ofcomputational models that can characterize and generate protein sequences forany arbitrary function. However, progress today is limited by lack of 1)benchmarks with which to compare computational techniques, 2) large datasets ofprotein function, and 3) democratized access to experimental proteincharacterization. Here, we introduce the Protein Engineering Tournament, afully-remote, biennial competition for the development and benchmarking ofcomputational methods in protein engineering. The tournament consists of tworounds: a first in silico round, where participants use computational models topredict biophysical properties for a set of protein sequences, and a second invitro round, where participants are challenged to design new protein sequences,which are experimentally measured with open-source, automated methods todetermine a winner. At the Tournament's conclusion, the experimental protocolsand all collected data will be open-sourced for continued benchmarking andadvancement of computational models. We hope the Protein Engineering Tournamentwill provide a transparent platform with which to evaluate progress in thisfield and mobilize the scientific community to conquer the grand challenge ofcomputational protein engineering.

The Protein Engineering Tournament: An Open Science Benchmark for Protein Modeling and Design