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We report on the observation of a rare neutrino event detected by Baikal-GVDin April 2021. The event GVD210418CA is the highest-energy cascade observed byBaikal-GVD so far from the direction below the horizon. The estimated cascadeenergy is $224\pm75$~TeV. The evaluated signalness parameter of GVD210418CA is97.1\% using an assumption of the E$^{-2.46}$ spectrum of astrophysicalneutrinos. The arrival direction of GVD210418CA is near the position of thewell-known radio blazar TXS~0506+056, with the angular distance being within a90\% directional uncertainty region of the Baikal-GVD measurement. The eventwas followed by a radio flare observed by the RATAN-600 radio telescope,further strengthening the case for the neutrino-blazar association.

Baikal-GVD Astrophysical Neutrino Candidate near the Blazar TXS~0506+056