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Photoacoustic tomography is a contrast agent-free imaging technique capableof visualizing blood vessels and tumor-associated vascularization in breasttissue. While sophisticated breast imaging systems have been recentlydeveloped, there is yet much to be gained in imaging depth, image quality andtissue characterization capability before clinical translation is possible. Inresponse, we have developed a hybrid photoacoustic and ultrasound-transmissiontomographic system PAM3. The photoacoustic component has for the first timethree-dimensional multi-wavelength imaging capability, and implementssubstantial technical advancements in critical hardware and softwaresub-systems. The ultrasound component enables for the first time, athree-dimensional sound speed map of the breast to be incorporated inphotoacoustic reconstruction to correct for inhomogeneities, enabling accuratetarget recovery. The results demonstrate the deepest photoacoustic breastimaging to date namely 48 mm, with a more uniform field of view than hitherto,and an isotropic spatial resolution that rivals that of Magnetic ResonanceImaging. The in vivo performance achieved, and the diagnostic value ofinterrogating angiogenesis-driven optical contrast as well as tumor mass soundspeed contrast, gives confidence in the system's clinical potential.

Fully three-dimensional sound speed-corrected multi-wavelength photoacoustic breast tomography