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We consider the Macdonald group $\langle x,y\,|\, x^{[x,y]}=x^{1+2^m\ell},\,y^{[y,x]}=y^{1+2^m\ell}\rangle$ and its Sylow 2-subgroup $J=\langle x,y\,|\,x^{[x,y]}=x^{1+2^m\ell},\, y^{[y,x]}=y^{1+2^m\ell},x^{2^{3m-1}}=y^{2^{3m-1}}=1\rangle$, where $m\geq 1$ and $\ell$ is odd. Then$J$ has order $2^{7m-3}$, and nilpotency class 5 if $m>1$ and 3 if $m=1$. Wedetermine the automorphism group of the 2-groups $J$, $H=J/Z(J)$ and$K=H/Z(H)$, where $|H|=2^{6m-3}$ and $|K|=2^{5m-3}$. Explicit multiplication,power, and commutator formulas for $J$, $H$, and $K$ are given, and used in thecalculation of $\mathrm{Aut}(J)$, $\mathrm{Aut}(H)$, and $\mathrm{Aut}(K)$.

The automorphism group of finite $2$-groups associated to the Macdonald group