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During the last 15 years bottom-up on-surface synthesis has been demonstratedas an efficient way to synthesize carbon nanostructures with atomic precision,opening the door to unprecedented electronic control at the nanoscale.Nanoporous graphenes (NPGs) fabricated as two-dimensional arrays of graphenenanoribbons (GNRs) represent one of the key recent breakthroughs in the field.NPGs interestingly display in-plane transport anisotropy of charge carriers,and such anisotropy was shown to be tunable by modulating quantum interference.Herein, using large-scale quantum transport simulations, we show thatelectrical anisotropy in NPGs is not only resilient to disorder but can furtherbe massively enhanced by its presence. This outcome paves the way to systematicengineering of quantum transport in NPGs as a novel concept for efficientquantum devices and architectures.

Tailoring giant quantum transport anisotropy in disordered nanoporous graphenes