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There is interest in comparing the output, principally the likelihood ratio,from the two probabilistic genotyping software EuroForMix (EFM) and STRmix.Many of these comparison studies are descriptive and make little or no effortto diagnose the cause of difference. There are fundamental differences betweenEFM and STRmix that are causative of the largest set of likelihood ratiodifferences. This set of differences is for false donors where there are manyinstances of LRs just above or below 1 for EFM that give much lower LRs inSTRmix. This is caused by the separate estimation of parameters such as alleleheight variance and mixture proportion under Hp and Ha for EFM. It results in adeparture from calibration for EFM in the region of LRs just above and below 1.

A diagnosis of the primary difference between EuroForMix and STRmix